The NOAA National Marine Fisheries Service Science Centers have state-of-the-art experimental facilities to study the response of marine organisms to ocean acidification. The Northeast Fisheries Science Center has facilities at its Sandy Hook , NJ and Milford , CT laboratories, the Alaska Fisheries Science Centers at its Newport , OR and Kodiak , AK laboratories, and the Northwest Fisheries Science Center at its Mukilteo , WA laboratory. All facilities can tightly control carbon dioxide and temperature. The Northwest Fisheries Science Center can also control oxygen, and can create variable treatment conditions for all carbon dioxide, temperature, and oxygen. These facilities maintain laboratories focused on chemical analysis and use standard operating procedures for analyzing carbonate chemistry to identify the treatment conditions used in experiments.

Research at these facilities focuses on economically and ecologically important species, ranging from phytoplankton to fish. Laboratory experiments explore how survival, growth, and physiology of marine organisms are impacted by ocean acidification, which can give scientists an understanding of how species may respond to ocean acidification in their natural environment. NOAA researchers use these data to explore how aquaculture, wild fisheries, and food webs may change as ocean chemistry changes.