Abundant and diverse cold-water coral and fish communities can be found in the deep waters of the Florida Straits, which are believed to be living under suboptimal conditions impacted by increasing oceanic CO₂ levels. Yet, little is known regarding the spatial–temporal variability of bottom carbonate chemistry parameters and their dynamic drivers in this area. To address this issue, we present results from numerical simulations of a coupled physical-biogeochemical model for the south Florida shelf and Florida Straits. Our exploratory analysis focuses on two well-known deep-coral habitats: Pourtalès Terrace (200–450 m) and Miami Terrace (270–600 m). Results suggest that bottom waters along the northern/western slope of the Straits are comprised primarily of the North Atlantic Central Water (NWCW) and Antarctic Intermediate Water (AAIW), driven by upwelling associated with the bottom Ekman transport of the Florida Current. Over the Pourtalès Terrace, both the meandering of the Florida Current and mesoscale eddies modulate the upwelling (downwelling) of cold (warm) waters. In contrast, Florida Current makes a sharp turn at the southern end of the Miami Terrace leading to persistent island wakes, frequent occurrences of a transient eddy, and strong upwelling of deep waters toward the platform of the terrace. Passage of the transient eddy often accompanies strong downwelling of warm waters and a return (southward) flow on top of the platform. Overall, bottom water properties including temperature (T), dissolved inorganic carbon (DIC) and total alkalinity (TA) show strong variability on weekly to monthly time-scales over entire Pourtalès Terrace and on the platform of Miami Terrac, mostly driven by physics. In deeper areas (>400 m), bottom water properties are fairly stable with both DIC and TA showing narrow ranges. Interestingly, waters over the southeastern portion of the Pourtalès Terrace show consistently warmer temperature, lower DIC, and higher TA than those on top of this terrace. The aragonite saturation state (Ω) ranges 1.2-2 on top of the Pourtalès Terrace and 1.2-1.7 both on top of Miami Terrace and on the upper slope of Pourtalès Terrace. In the deeper slope areas (>400 m), it is nearly constant at 1.2-1.3. This modeling effort suggests that remote forcing and biogeochemical processes along the transport paths, from the Gulf of Mexico to the Straits, are significant but second-order contributors to the variability of bottom carbonate chemistry. The impacts of benthic biogeochemical processes along the transit paths are not resolved.